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The alternative to the iodine contrast media which used in CT-scan, it is the only contrast media currently used to obtain X-ray images for all the body organs requiring more accurate diagnosis of certain diseases, especially tumors, urinary system, blood vessels and heart, has been studied. But iodine compounds may cause an allergic reaction for the patients to this substance or cause blood clotting or dangerous interferences with certain diseases such as kidney disease (kidney failure) and other symptoms which cause the patient to be prevented from accurately diagnosing the disease. The first alternative contrast media is manganese chloride nanoparticles (MnCl2 NPs). The alternative nano contrast medium of MnCl2 NPs solution has been studied in good results comparative with iodine contrast medium especially in the heart organ by Hounsfield unit (HU) of CT-scan with the high resolution of imaging when using the low dose of alternative nano contrast medium comparing with native case and iodine contrast medium.