Age-Linked Variations of troponin-I Values in Patients with Acute Coronary Syndrome

Abstract

Background: The cardio-peptide troponin-I (CTn-I) can regulate actin-myosin cross-bridging, specifically to cardiomyocytes. Age alterations in the levels of CTn-I levels have become a new debatable emphasis. As well, it is frequently hard to interpreting how to manage aging people when a high CTn-I level is noticed. Acute coronary syndrome (ACS) is the principal cause of mortality worldwide mainly in elderly people. In the present work, we aimed to determine whether an increased CTn-I level varies with age in patients with ACS. Methodology: This observational study, involved 150-patients diagnosed as ACS during the period from January to March 2021 from patients attending the ED of Alimam-Alsadiq hospital. Hematological investigations had started at the time of presentation included creatinine, urea, and serum CTn-I. Results: mean applicants' age was 59.7years (> 3/4th were men), and the mean BMI was 27.0±5.0kg/m2. The current smokers represented 43.3% of the total. Likewise, the incidence of DM and hypertension were significantly high (42% and 49.8%) respectively. Blood chemical analysis revealed mean creatinine, urea, and CTn-I values were 85.2±9.0mmol/l, 14.1±3.6mmol/l, and 8.9±0.4ng/ml consequently. The sex revealed no much influence on most of the included variables apart from CTn-I that was lesser in females (p-0.005). Risk factors were significantly (p-0.001) more among males, which not the case for the incidence of DM. There were no significant deviations of concentrations of CTn-I with increasing ages of ACS patients (P>0.05). Conclusion: This study highlights that in patients with ACS presented to ED, the routine of CTn-I for the diagnosis of ACS should be interpreted based on the patient's age/sex to adjust diagnostic precision of CTn-I for both sexes.