Pathological and Cytogenetically Study on the Toxic Effect of Inhaled Benzene among Male Rats

Abstract

Thirty six Swiss albino male rats, in 12 weeks study exposure whole body (inhaled) to benzene at concentration of 0 , 400 ppm , 800 ppm = ( 0 , 672 mg / m 3 , 1.343 mg / m3) respectively, 5 hr. / day for 4 days / week for 12 weeks. Cytogenetic examination by micronuclei (MN) assay and chromosomal aberrations (CA) of the three groups at 6 and 12 weeks of exposure, were significantly increased P<0.01 specially in 800 ppm group at 6 weeks of exposure, Exposure rats to benzene reported clinical signs characterized by hypoactivity and convulsion .Histopathological lesions revealed neoplastic lesion in bronchi lung with liver adenocarcinoma than those observed in historical control.