The Impact of Toxoplasma Gondii Infection on the Level of Shla-G and its Receptor in Iraqi Patients Infected with Rheumatoid Arthritis

Abstract

Rheumatoid arthritis is an autoimmune disease characterized by insistent inflammation of joints which will developed to damage of cartilage and effect on the life quality and mortality. 196 subjects were included in this study, divided into (RA+ve toxo-ve , RA+ve toxo +ve, Toxo + ve RA -ve, and RA-ve toxo -ve groups . The C-reactive was measured, Rheumatoid Factor, and anti- Toxoplasma gondii (IgM and IgG), and Human Major Histocompatibility Complex class 1G, and Human Leukocyte Immunoglobulin Like Receptors sub family B member 4 by ELISA method using (My bio source kits/USA).The result showed that the percentage of patients who had positive this study included only patients with positive results for both tests CRP and RF which was just (64%), and The results showed that treated RA patients without Toxoplasma had the highest significant (P≤0.01) increase level of sHLA-G in comparison to RA untreated patients, also treated RA co infected patients with Toxoplasma showed high significant increase (P≤ 0.01) of sHLA-G in comparison to co infected untreated, while the level of sHLA-G in patients with toxoplasmosis only significantly (P≤0.01) increased in comparison to RA-ve toxo -ve, whilst that