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The standard diagnosis of sepsis is blood culture examination which takes a relatively long time and is only a few positive results. Various biomarkers have been developed to diagnose sepsis. One of them is procalcitonin. Although considered a better marker of sepsis, PCT is relatively high cost and is not readily available in many hospitals. In recent times, a number of simple parameters, which come from complete blood counts are quite cheap, fast and common. Its use as a biological marker has been studied, namely the neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR). Mean Platelet Volume - Platelet count (MPV / PC). This study will look at the suitability of the neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR). Mean Platelet Volume - Platelet count (MPV / PC) with procalciotonin levels in patients diagnosed with sepsis at Wahidin Sudirohusodoada Hospital, Sepsis Patients. The study population was all inpatients with a diagnosis of sepsis at Dr. Wahidin Sudirohusodo in Makassar criterion Age> 18 years, and has data on routine blood laboratory results and procalcitonin. Sampling was done by consecutive random sampling. Based on a study of 48 sepsis patients aged 20-81 years, the mean age was (47.7 ± 12.7). The number of respondents consisted of 26 men (54.2%) and 22 women (45.8%). There was no compatibility between NLR and Procalcitonin (r = -0.078 p> 0.05), MLR with Procalcitonin (r = -0.052 p> 0.05), PLR with Procalcitonin (r = -0.179 p> 0.05). And the final result is that there is a significant positive agreement between MPV / PC and procalcitonin, (r = 0.317 p <0.001). There was no correlation between NLR, MLR and PLR values with prokalistonin levels in septic patients. There is a significant correlation between the MPV / PC ratio value and the procalcitonin level in septic patients. In patients with sepsis the MPV / PC ratio value can be used as an alternative as a substitute for prokalastinonin testing which is considered expensive and difficult to do in limited areas.