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Talc is a rich in a magnesium silicate mineral of many base metal sulfide ore deposits that occurs as a gangue component around the world which is used in the pharmaceutical industry as a raw material of mineral origin. Talc quality for pharmaceutical raw material pharmaceutical uses is regulated by pharmacopoeias, which include several chemical and physicochemical tests. The aim of this study was to discuss the talcum powder: uses, safety, application, and estimate the presence of calcium quantity in four selected samples by complexometric titration in the presence of EDTA and EBT as indicator. The results of the study showed among the four selected sample, Ashoka has highest quantity of calcium among the others.