Oxidants and Antioxidants levels in blood of mice that orally dosed with Silver – Copper (core-shell) Nanoparticles

Abstract

The current study included the preparation of the silver-copper nanoparticles Ag-Cu NPs in the form of a core-shell, and the hybrid compound from loading the commercial drug Albendazole on the nanoparticlesAg-Cu NPs /Alb , and diagnosing it with tests FTIR, AFM , XRD and SEM , then this compound was dosed orally to laboratory mice at concentrations of 400, 800 and 1200 mg/km for two days / one dose per day in order to know the effect of these compounds on the value of some oxidants and antioxidants compared with Albendazole and distilled water as control agents. The results showed that the oxidative value of MDA did not change compared to the control treatment except for the concentration of 800 mg / kg of Ag-Cu NPs , as well as ROS . The value of antioxidants did not change from the control treatment for both Catalase and Glutathione, except for the concentration of 400 mg / kg of the Ag-Cu NPs /Alb , whose value was increased compared to the control.