The Possiblee of Tuberculosiso Selected Interleukinsa Neurotransmitters among Displaced Iraqi Peoples

Abstract

Background: Tuberculosis  is  one  of the  world’s  oldest  and  most important disseminating infectious disease  that still accounts for a high morbidity and mortality among adults particularly in  developing  countries including Iraq which suffered from migration and displacement of millions of peoples due to series of wars ended by ISIS terror and invasion. Tuberculosis  might  cause  changes in activity  of  neuro modulating  factors as well as in the behaviour of the immunological responses including cytokines at the same time. Methodology: In the current study there were 50 patients (18 displaced and 32 non displaced TB patients) and 40 healthy control.Interleukins-6, interleukin-10, acetylcholine and serrotinin were estimated in the seum of those patients examined. Results: interleukin (IL-6),interleukin(IL-10), serrotinin (ST)and acetylcholine(ACH)  concentrations showed various differences individually and/or together  with respect to patients  origin  and   gender in comparison  to non-TB control individuals. Conclusions: Serum cytokines IL-6, and IL-10 were elevated. Neurotransmitter    likes eroton in and  acetylcholine were significantly correlated with each other and with cytokines studied which revealed a synergistic effect of tuberculosis on the values estimated of both cytokines and neurotransmitters.