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Solubility, which is one that relates with the dissolution is a very important factors that relates with the pharmacological action of a drug. This is because it is to achieve the minimal or desired concentration in the blood circulation for a drug to give its pharmacological effects. More than 40% new chemical entities are found to be insoluble in water. The solubility of the active ingredients of the drugs is then be the main problems for the researchers these days. Therefore, there are a few techniques which we can use to improve the solubility of the drugs such as particle size reduction. Dissolution is also important for drugs to be absorbed into the blood circulation. Therefore, for oral taken drugs, usually dissolution testing is needed to have a better control of the product’s activity throughout its life cycle.