The Role of Pro-inflammatory and Anti-inflammatory Interleukins in the Repair of Experimental Soft Tissue Injuries Complicated by Textile Foreign Bodies

Abstract

The healing of wounds resulting from the use of military weapons can be complicated by the presence of foreign bodies. This work aimed to study the effect of textile foreign bodies on the production of interleukins during the repair process. 60 rats were divided into 4 groups: intact (IG), control (CG), and two experimental (EG1, EG2). In CG, wounds were sutured without implantation of foreign bodies. A uniform consisting of 100% cotton was used as foreign bodies for EG1, a uniform consisting of 65% cotton and 35% polyester - for EG2. A violation of the dynamics of production of interleukins was registered. The values of IL-1β and IL-6 in EG1 after 60 days exceeded the values in CG 2.07 times and 2.92 times, and in EG2 - 1.37 times and 2.35 times, respectively (p<0, 05). The content in the experimental groups of IL-4 increased on the 30th day, and IL-10 - on the 60th day, but was lower than in the CG. The presence of textile foreign bodies in wounds created unfavorable for healing, which disrupted the production of interleukins. High levels of IL-1β and IL-6 throughout the experiment in animals with textile implants confirmed the prevalence of pro-inflammatory mechanisms, which significantly slowed down the process of damage repair.