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Background and Aims : Piper betle leaves is the medicinal plant that has been used as the traditional medicines as an antifungal to help vagina or oral candidiasis.The extract of the Piper Betle has significant functions that may help as an anticandidal effect against the Candida albicans, and Candida glabrata, The study was designed to formulate and evaluate the characterization and the effectiveness of the feminine wash with the extraction of plants Piper Betle.L that may help in treating the Candidiasis that provides the best patient compliance with the minimal side effects. Method: The maceration method was used to prepare the extract. Three different concentrations of Piper Betle feminine wash, such as 250 mg/ml, 125 mg/ml and 62. 5 mg/ml were formulated and tested with the Candida Albicans sp..using disc diffusion method and zone of inhibition was compared using negative control. The physical evaluation of preparation of feminine wash including the pH test, appearance, and color were conducted. Result and Discussion: The formulation of 62.5 mg/ml feminine wash with Piper betle extract was effective against the Candida Albicans sp. with the diameter zone inhibition of 19 – 21 mm. This indicates that the formulation with 62.5 mg/ml of extraction is effective and can be used as topical drug delivery. Conclusion: It is found that the concentration that is most effective against the antifungal properties was 62.5 mg/ml Piper Betle Feminine wash formulation.