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Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense RNA enveloped virus. It is characterized by club-like spikes that form unusually large RNA genomes from their surface and are a unique replication strategy. SARS-CoV-2 causes several diseases and distress in human and potentially fatal respiratory infections. COVID-19 caused by SARS-CoV-2 is a pandemic disease which has led to a global health crisis resulting in millions of deaths worldwide. The following is a brief introduction to the SARS-CoV-2, particularly discussing its replication, pathogenicity, and neurological complications.