Preparation and Characterization of Lamotrigine Mucoadhesive Tablets with Natural Polymers

Abstract

Lamotrigine is an anticonvulsant drug and reported lower bioavailability of conventional tablets. Hence it is required to make such a dosage form having improved bioavailability compared to conventional dosage form. The present study was planned to formulate and characterize the mucoadhesive tablets of Lamotrigine employing different proportions of natural polymer acquired from the Okra and Hibiscus rosasinensis. The six formulations (L1 to L6) of mucoadhesive tablets were prepared by following direct compression technique. The prepared formulations were evaluated by checking their strength of thickness, friability, hardness, weight variation, drug content, surface pH, mucoadhesive strength, mucoadhesion force, swelling index and in- vitro dissolution studies. The findings showed the formulations containing higher amounts of gum Okra and Hibiscus rosasinensishave better mucoadhesion strength. The drug release demonstrated 12 hr for the complete release of drug from formulation suggesting sustained release pattern. The mucoadhesive tablets of Lamotrigine enhanced the systemic absorption due to higher permeability with a rich blood supply to mucus layer.