The Gene Expression of ADAM9 in patients with gastric cancer in Iraq

Abstract

ADAM9 disintegrin and metalloproteinase domain 9 gene, has been institute, and characterize overexpression, and dysregulation in a different of solid tumors. Objective: Evaluation the Gene Expression of ADAM9 in gastric cancer patients in Iraq. Furthermore, found the correlation between ADAM9expression, and clinic-pathological parameters.50 randomly patients FFPE blocks of stomach tissue (10 normal & 40 patients GC) were collected from the Gastroenterology and Hepatology Teaching Hospital. ADAM9 Gene Expressionhas been achieved by using qPCR. Statistical analysis accomplished by SPSS system at (P<0.05). This study indicated that there were a significant differences between control and patients, also there was a significant correlation in invasion depth, lymph node involvement, and stages in patients, whereas there was non- significant association between the age, grade, gender, and histopathological type of patients in the expression of ADAM9. These results indicated that ADAM9 could be a functional target for advanced gastric cancer therapeutic.