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The present investigation was carried out to get it some model distinctions among the content of LBSA and the vigor of SOD in serums of normal donors (n=10) and patients with breast cancer (premenopausal n=20, postmenopausal n=20, and benign n=20). Data analysis show a lesser SOD activity in the serum of breast cancer patients (premenopausal 1.29 ± 0.14 and postmenopausal 1.05 ± 0.23) as compared to the benign patients 1.53 ± 0.17 and normal controls 1.65 ± 0.21, whereas, LBSA levels in sera of breast cancer patients show a significantly higher increase (premenopausal 29.32 ± 3.55 and postmenopausal 27.35 ± 5.29) than in benign patients 18.73 ± 2.29 and normal healthy 16.9 ± 2.13 respectively. The ratio of LBSA/SOD was higher in patients with breast cancer. On the other hand, a negative correlation (P > 0.001) exists between LBSA and superoxide dismutase in the serum of breast cancer patients. Results of this research show that SOD and LBSA to be delusory features of malignant with possible, usefulness in another cases connected with an raise hazard of neoplastic development in bonus to breast cancer.