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Nursing has been identified as one of the most stressful jobs. Job stress in nurses affects both individual and organizational functioning as well as health care. A descriptive study was conducted among the nurses of the critical care units in the medical complex city to evaluate job stress. A non- probability (purposive) sample of (200) nurses who were working at critical care unit.The result reveals that, all staff nurses who working in critical care unit suffer from stress; that nurses working in critical care units are experiencing severe level of job stress (71%). They study shown that no a significant relationship among overall stress and all demographic data in present study.Stress management strategies should be design to assist critical care nursing staff to deal with job stress and help them to deals the difficulties generated by job pressures to improve the quality of nursing care, Hospital administration support services should be established for at-risk groups to relieve stress.