Fetal Teratogenic and Histopathological Influences of Tramadol on White Rat Fetuses
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Abstract
Tramadolisan effective opioid analgesic that is widely used in the world to relieve moderate to severe pains, because there are not insufficient information’s of this drug on fetal parameters and histological effects on the fetuses, this study wasdesigned, 12 pregnant white rats(Rattus rattus) were used in current study to indicate the fetal teratogenic and histopathological changes of someorgans(brians and livers)of fetuses for a pregnancy period of 20 days,the means ofbody weight and age of pregnant rats were (210.5gand 11.5weeks )respectively, these pregnantanimals were individed into 3 groups:the first group was treated with normal saline (control group)(n=4), second group was treated with tramadol drug with concentration of 125mg/kg (n=4) and third group was treated with tramadol drug with concentration of 200mg/kg (n=4),pregnant rats in all groups were administrated from the 1st pregnancy day and dissected on the 20thday of it.
Current study results revealed a significant increase(P <0.05) in the number ofdead fetuses andnumber ofundeveloped fetuses in treated groups with tramadol drug of two doses(125 mg/kg and 200 mg/kg)respectively,whereas number offetuses in two uterine hornsand number oflivefetusessignificantly decreased(P <0.05) in treated groups with tramadol drug of two doses(125 mg/kgand 200mg/kg) respectively compared with control animals group, as histological study showed that of different pathological changes occurrence in the organs of fetuses whose their mothers were treated with two doses of tramadolduring pregnancy when compared with control rats group,and these effects were more severe at the higher drug dose.
The conclusion/based on the results of our current study which in it tramadol drug was administered from the first day of pregnancy, this drug had a toxic influences on the various fetusgenesis processes and stimulatedvarious pathological changes inbrain and liver tissues of fetuseswhich increased with increasing drug dose.