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Huntington's disease (HD) isa neurodegenerative disorderand generally related to a mutation in a gene. The mutation leads to the increasing in the triplet CAG repeating inside the coding section of the gene.Characteristics of Huntington's disease including the presence of 2 symptoms: abnormalities in the motor nerve cells and impairment of cognition.Nearly 9% of cases symptoms may begin earlier the age twenty years, in this case the disease identified as adolescent HD.The review aimed to study the huntingtons disease signs and symptoms, learning about causes and risks, Knowing the genetics of HD and types of antioxidant therapies used in HD. We concluded from the current review that HD is a disorder which has been stubborn to the treatment. In our review, we propose the using of antioxidants in the achievement of the disease state. Free radicals generation leading to the condition of oxidative stress (OS) destruction that causing loss of nerve cells in HD. Supplementation with antioxidants from natural source may cause reducing of oxidative stress that responsible for the pathophysiology of different dangerous illness for example,neurodegenerative illnesses. Oxygen Species mostly a free radical types that responsible for cells damaging and consequent death of cells because of the oxidization to sensitive constituents of cells that makes part of lipids, proteins, DNA, RNA. Glutamic acid is the main amino acid that preventing the neurodegeneration which responsible for HD people that are at great danger, as aged and newly detected patients.