Preparation, Characterization of some Thiazolidine Derived from Penicillamine and their Antioxidants Activity

Abstract

A new series of thiazolidine-4-carboxylic acid derivatives of penicillamine have been synthesized in one step by cyclization of penicillamine with different aromatic aldehydes. The optimized reaction conditions for this one -pot reaction were achieved. The products were obtained in short reaction times, high yields and high purities". All products were characterized and identified by FT.I.R and ¹H-NMR spectroscopy and Finally in vitro antioxidant potential for the new prepared products was evaluated according to the 1,1-diphenyl-2-picrylhydrazyl (DPPH)"radical scavenging assays. Some of synthesized compounds showed a good antioxidant activity which supports the favorable influence of the structural modulation on the antioxidant effects of the aromatic aldehydes".