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Background: Stroke patients with PSD at the second week, third month, and sixth month after the attack are at risk of having recurrent strokes. Cognitive-behavioral therapy (CBT) intervention identifies and changes negative thought patterns and behaviors that lead to physical-emotional disorders. This study aims to determine the effect of cognitive behavior therapy (CBT) on reducing depression in post-stroke ischemia patients.The study was conducted with a quasi-experimental design conducted on 80 respondents divided into 40 respondents in the intervention group and 40 respondents in the control group selected by consecutive sampling technique. CBT intervention was given to control group respondents for 3 days. Post-ischemic stroke depression scale assessor using the HDRS instrument. The analysis was performed using univariate analysis and bivariate analysis using a statistical t test.It was found that the CBT intervention given to the intervention group showed a decrease in the depression score of post-ischemic stroke patients compared to the depression score of post-stroke patients in the control group (p value 0.000).CBT intervention given to patients with post-stroke depression is able to have a good effect on reducing depression in post-stroke ischemic patients. Health services that provide care services for patients with post-ischemic stroke depression are advised to provide CBT interventions to patients to reduce post-ischemic stroke deepest scores.