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Celiac disease is an autoimmune enteropathic disease brought about by consuming gluten in people who are genetically predisposed by carrying HLA DQ2 or/and HLA DQ8 genotypes.
To evaluate the distribution of human leukocyte antigen (HLA)-DQ2 and -DQ8 and their relative riskwith celiac disease (CeD) in Syrian patients comparedto healthy Syrian controls.
Genotyping for unrelated CeD patients (n = 100) and unrelated matched healthy controls (n = 100) was performed to identify DQ2 and DQ8 alleles by SSP-PCR
In this case control study 82% of CeD cases and 24.5 % of controls were carriers of HLA DQ2 whereas 18 % and 8.5 % ofCeD patients and controls respectively carried HLA DQ8. The highest risk for the development of CD relating to HLA-DQB was found in patients carrying DQ2.5/DQ8 genotype and DQ2.5/DQ2.5 (1/10) and the lowest risk was found in patients with DQ2.2/DQ8 genotype.
In Syrian Patients, celiac disease is strongly related to HLA DQ 2 and DQ 8 genotypes and thus these possess a high positive predictive value for the diagnosis of celiac disease. Additionally, our study highlighted the integral part of these genotypes in the pathogenesis of celiac disease.