Main Article Content
Connective tissue dysplasia (CTD) is a unique ontogenetic anomaly body development, which is one of the complex topics with insufficient number of researches have been done in modern medicine and is the morphological basis of the functional changes in cardiac activity. We studied 115 children of preschool and school age with connective tissue dysplasia and small heart development abnormalities. A high frequency of occurrence of external phenotypic markers of connective tissue dysplasia syndrome (CTDS) and stigma of embryogenesis was revealed. An increase in the average level of HOPof spine in blood serum in children with Minor Cardiovascular Development Abnormalities (MCDA)in combination with cardiovascular pathology and patterns characterizing the relationship of the clinical manifestations of the disease and mineral imbalance has been established.