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The incidence of tuberculosis (TB) in the Republic of Uzbekistan, according to the expert commission of the World Health Organization (2018), tends to decrease. So, in 2011, it was 52.4 per 100 thousand population, and already in 2018 - 42.5 per 100 thousand population. Until now, there is no official statistics on the registration of diseases caused by NTM in Uzbekistan and it is not possible to reliably assess the incidence rate. The study involved 15122 case histories who had applied to The Republican Medical Center of Phthisiatry and Pulmonology under the Ministry of the Health of Uzbekistan. The ATS/IDSA diagnostic algorithm was used as the criteria for non-tuberculosis mycobacteria detection.Out of 15122 patients, nontuberculosis mycobacteria were detected in 61 (0.41%) patients; while Mycobacterium avium Complex - in 19 (0.13%), Mycobacterium fortuitum - in 9 (0.06%). According to the results of a retrospective study of the treatment results it was revealed that NTM are detected annually in biological samples of 0.4% patients.