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Introduction: Myocardial infarction (MI) is one of the greatest frequent encounter causes for hospital admittance besides is common see in all populaces worldwide. The limit researches are carry out in Kerbala Province populace, and we object to examine the molecular relationship of single nucleotide polymorphism (SNPs) recognized done GWAS investigates in Myocardial infarction patient groups in Karbala Province populace. Method: The case-control study design. This study involved (140) samples collected from patients with MI and control group. The blood five ml samples determination by collect in two changed tubes, besides 3mL of coagulate blood determination to use for biochemical analysis (lipid tests) besides 2mL determinate to use for molecular (DNA) analysis. Genomic DNA determinate extract by collect blood sample, besides specific primer can be design for chose SNP (SORT1-rs464218 polymorphisms) beside use Genotype technique is Allele specific-PCR. Results: The rs464218 polymorphisms was significant associate with genotype in Odd Ratio (O.R.) analysis (p < 0.05) in Heterozygous genotype (GA) of SORT1 gene. The correlate in the middle of lipid profile, BMI and genotype have shown non association of rs464218 variant by combine parameters, the ANOVA analyse is carry out by research effect of (rs464218) variant on variance parameter. The analyse distribute of the variable around various genotype in select polymorphism. BMI was non-association with any of genotype in (rs464218) variant. Also the non-association in result with TG, TC, HDL-C, LDL-C, VLDL-C in (rs464218) SORT1 gene (p=0.255), (p=0.31), (p=0.187) (p=0.416) and (0.213) were non-significantly associated variants respectively. Conclusion: The outcomes of this research confirm the (rs464218) polymorphism in SORT1 gene SNP is associated in Kerbala Province populaces.