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Introduction: organophosphorus (OP) is a fundamental general medical condition. In Southeast Asian nations, they deliberately hurt themselves with around 5,00,000 passings each year, and around a little over half of these passings are brought about by pesticide harming. The three enzyme pathways mixed function oxidases (MFO), hydrolases, and transferases are involved within the bio-transformation of Organophosphorus. The aim here is to assess the severity of organophosphorus compound poisoning through Peradeniya organophosphorus score and serum cholinesterase levels. The method that we have adopted for our research is carried on patients with history of organophosphorus compound consumption, who were admitted in medical intensive care units in Krishna hospital and medical research centre, Karad during the study period of 18 months. Result is 78 patients who presented with organophosphorus compound consumption in our hospital during October 2018 to March 2020. Most of the patients were in the age group of 21-30 years with a minimum age of 17 years and maximum age 78 years, mean age of 33.4± 14.2 years with male preponderance and male to female ratio of 1.5:1. A total 21.8 % of the patients had heart rate less than 60 beats per minute. About half of the patients with OP poisoning had small size pupils, there were 1.3% patients who were drowsy whereas 5.1% patients were unconscious, generalized fasciculations were observed in 19.2% patients and none of the patients developed seizures. The study concludes that Organophosphorus compounds are one of the frequently consumed poisons with lethal complications such as respiratory muscle paralysis leading to respiratory failure which requires ventilator support.