EXERCISE PARAMETERS FOR REDUCING FATIGUE IN PATIENT WITH IDIOPATHIC PARKINSON'S DISEASE – SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract

Background:Very few studies have shown their effectiveness on fatigue or in any other non-motor symptoms in Parkinson’s Disease. This remains controversial and difficult in choosing the treatment protocol which has been not the same among various therapists. Objective: -The purpose of this systematic review is to explore the exerciseparameters and express the need for non-invasive biomarkers for fatigue.Methods: -A total of 2302 articles from the Electronic databases from Jan 2010 to Jan 2021 were extracted. After applying the eligibility criteria 7 RCT studies were considered. Results: - 5 RCTs were reported until now with an average of 5.8 out 10 on the PEDro scale. None of the studies used any type of biomarker as an objective outcome measure for analysing fatigue.Conclusion: -Exercise interventions have proven to be the best source of reduction of fatigue in Parkinson’s disease. But very fewer studies have been done, where enough data are unable to reproduce them in another setting. Hence, there is an extensive need to conduct more Randomized control trials with feasible non-invasive Biomarker the evaluate the treatment progression