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Parkinson’s Disease is the commonest neurogenerative disease secondary to Alzheimer’s disease, it has taken a pattern of a pandemic affecting cross countries, religions, cultures, and ethnicity. 150 years since its emergence in the medical diagnosis India has been the 13th country to be a contributor to the global publication output in PD among 15 competing countries. 2013 fatigue was reported to be most disabling in the World Parkinson’s Congress by the patients who participated in the conference. With the increasing industrialization, aging, and smoking cessation the review article strongly raises the need to do extensive in-depth research on the objective assessment tools like salivary biomarkers as cortisol which can be a benchmark of prognosis for the interventions applied. There is a need for a robust protocol for treating fatigue and it is believed that targeting fatigue as a separate element from the initial stages would reduce the severity of the disease, improving the quality of life of the patients and their caregiver also with a reduction on the financial aspects which has led to increased drops from the therapy sessions.