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Background: The present study investigated and compared between the potential effects of free gingival graft alone or in combination with Injectable Platelet-Rich Fibrin (I-PRF) on root coverage surgery.
Material & Method: Total of 40 subjects with Miller class I or II gingival recession were included. The subjects participated in the present study were randomly divided into 2 groups, i.e., control and experiment groups. The subjects in the control group were treated only with the free gingival graft (FGG), whereas the subjects in the experiment group were treated with the combination of free gingival graft and injected with I-PRF as a root surface biomodification agent (FGG+I-PRF). The subjects were reviewed again after 3 months, and amount of exposed root surface was determined and compared to that of the preoperative findings. Results: The mean initial exposed root surface was 4.7±1.50 mm for experiment (FGG +I-PRF) group and that of the control (FGG) group was 4.1±1.09 mm and 4.5±1.32 mm for all subjects. The mean root surface coverage values of the 2 groups three months after the operation were 3.5±1.05 in the control and 3.9±0.78 mm in the experiment group. Conclusions: The findings in the present study showed that Injectable Platelet-Rich Fibrin (I-PRF) had a positive effect on the root coverage as compared to only free gingival graft in free gingival graft surgery.