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BACKGROUND:Sepsis is a medical emergency which involves response of the immune system of body for an infectious process leading to the end-stage dysfunction of the organs and death. Sepsis is amongst major causes of the morbidity and mortality in terminally critical patients in the world.Organ dysfunction is identified by little change in the SOFA score i.e., score of two points or more. In spite of advancements in the knowledge of sepsis- its pathophysiology, and developments in tools of monitoring and resuscitative measures, still sepsis has been one amongst major causes of morbidity and mortality in terminally critical patients. This study has been planned to evaluate the ability of serum lactate to albumin ratio as a prognostic marker in patients of sepsis.