Cytokine Bombardment is the Major Cause for Morbidity in Sars-Cov-2 (Covid-19) Patients: A Review

Abstract

Cytokine bombardment is described as dysregulation and excessive production of cytokines. It causes fatal outcome in COVID-19 patients and result in acute respiratory distress syndrome. The most vulnerable group includes children, old age people and individuals with underlying conditions. In this group, COVID-19 infection initially presents with acute respiratory distress syndrome and further progresses to multiple organ dysfunction, sepsis and death. The present review describes the cytokine storm based hyper-immune response mechanisms in these patients through schematic diagrammatic representations.