The Role of Some Blood Parameters Andmethylenetetrahy Drofolate Reductase Polymorphisms in Vitiligo

Abstract

The aim of study was to determine the relationship between Methylenetetrahydrofolate Reductase Polymorphisms in vitiligo with some clinical and blood parameters which include amount of hemoglobin in whole blood , RBCs and WBCs , the study included 60 patienthave been diagnosed with Vitiligo and 40 healthy people as a control group . The samples were collected from, Al-Kafeel Specialist Hospital, Imam Al-Hussein Teaching Hospital, blood were examined for all patients and control, and genetic polymorphism of gene rs1801133 C / T were studied using PCR-ARMS technology, the results were as follows: According to the of age of the subject were classified into five groups (5-15 years, 16-25 years, 26-35 years, 35-45 years, 46-55 years) the number and percentage of each category in vitiligo patients was 5 (8.33%), 6 (10%), 12 (20%), 17 (28.33%), 20 (33.34%) respectively, and while the healthgropuswere as follows: 4 (10%), 5 (21.5%), 8 (20%), 10 (25), 13 (32.5%), respectively. As the results showed by dividing the healthy and patient according to gender, the percentage of males was found in 34 (56.66%) and females 26 (43.34%), compared with the control group 50% for both sexes, allele frequency and genotype frequency. On the other hand the Methylenetetrahydrofolate reductase polymorphism was determined as the following : AA genotype, was recorded as 13 patients, AT genotype 27 and TT genotype was 20, while in healthy subjects 10, 11, 19 for each of the TT, AT and AA genotypes, respectively.