Study of Frozen Section in Oral Cancer in Context to Metachromatic Stain

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Dr. Pragyamita Datta, Dr.Kishor Hiwale, Dr.Sunita Vagha


Background–Oral cancer is a malignant lesion that appears on the lip or mouth cavity. Is occasionally described as a squamous cell carcinoma (OSCC), because it is in the dental area, 90% of malignancies histologically emerge from the squamous epithelial cells & oral cavity is basically lined by squamous lining.  Oral cavity squamous cell carcinomas (OSCCs), responsible for 3-5 percent of all malignancies, are the eighth most prevalent cancers in the world out of 10.  In order to reduce the possibility of recurrence to zero, diagnosis isusually lead by quickoperative removal of the malignancy with safer surgical or operative margins, which seems to be practically improbable. The perplexed oral cavity anatomy which make it problematic for the person who performs the operation to properly judge surgical borders of oral malignancies in a pinpoint manner and positive surgical boundaries compromise local and regional disease control, thus surgeon usually rely on frozen section or cryosections for proper assessment and identification of clear surgical margins. So frozen sectioning assessment of surgical boundaries is emerging as a very accurate identification tool in oral malignancies. Now the needful is to identify the active soft tissue boundaries of the tumour in the OT table itself, so that they can be removed properly. Frozen sections (cryosections) are a pathologica facility use for prompt micro anatomical examination and for specimen or disease diagnosis, typically used for oncological surgery and intra-operative rapid diagnosis.

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Dr. Pragyamita Datta, Dr.Kishor Hiwale, Dr.Sunita Vagha. (2021). Study of Frozen Section in Oral Cancer in Context to Metachromatic Stain. Annals of the Romanian Society for Cell Biology, 4110–4118. Retrieved from