The Effects of ANGPTL8 Levels and Correlated with Lipid Profiles and Insulin Resistance in Iraqi Patients with Overt and Subclinical Hypothyroidism

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Hussain Naeem Abd Ali, Hanaa Addai Ali


Hypothyroidism is a disease that is characterized by abnormally low thyroid hormone production and excretion by the thyroid gland T3 , T4 ,these Hormones regulate the body's metabolism, Angiopoietin-like peptide-8 is a glycoprotein-structured adipokine synthesized in adipose tissue and the liver. It paly a role in energy metabolism by inhibiting lipoprotein lipase, the key enzyme in the hydrolysis of plasma lipoproteins. Also , thyroid hormones play an important role in energy metabolism, therefore, the aim of the present study was to explore serum Angptl8 and its correlation with lipid profile and insulin resistance in hypothyroidism patients .
A case control study comprised of 90 eligible participants were included and divided into three groups including (overt hypothyroidism group = 32 ),( subclinical hypothyroidism group =28 ), ( healthy group = 30 ). were age-matched to the patient . ranged from (20 – 50 yrs.) Also , included females, with 55.5% of the participants being female and 44.5% of the participants being male. To if serum ANGPTL8 levels were significantly higher in patients with overt and subclinical hypothyroidism compared with control group. The level of ANGPTL8 is an indicator risk of hypothyroidism when the level of ANGPTL8 rises, patients experience hypothyroidism complications.
The study's findings The means levels of the BMI, serum TSH, FSG, Insulin, TG, cholesterol, VLDL-C, LDL-C, and Angptl 8 and HOMA- IR were significantly higher in all hypothyroidism patients group , except in a sub clinical group HOMA-β have a non-significantly when compared with healthy control group .while The means levels serum of the T3 , T4 , TG, Tc, and Angptl 8 were higher significantly in overt hypothyroidism when compared with subclinical hypothyroidism as shown in in table ( 1 ) , In overt hypothyroidism angiopoietin like 8 significant positive correlation with BML , TSH ,FSG ,insulin , HOMA IR , TC , LDL , VLDL and TG As وfor negative correlation HOMA-β and HDL. while In sub clinical hypothyroidism angiopoietin like 8 significant (positive )correlation with FSG , TG ,T4 , LDL -C, and VLDL _Cو ,As for significant negative correlation with HDL.
Conclusion : serum circulating ANGPTL8 levels are increased in patients with hypothyroidism and associated with change in lipids profile and HOMA-IR. the elevated levels of ANGPTL8 in hypothyroidism especially in subclinical hypothyroidism patients high light their potential involvement , their potential role as predicator marker for metabolic disorder ,T2DM their role in regulating the activity of lipoprotein lipase , a key enzyme in metabolism of lipoprotein .

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Hanaa Addai Ali, H. N. A. A. (2021). The Effects of ANGPTL8 Levels and Correlated with Lipid Profiles and Insulin Resistance in Iraqi Patients with Overt and Subclinical Hypothyroidism. Annals of the Romanian Society for Cell Biology, 25(6), 169 –. Retrieved from