Study of Galectin -3 Expression in Breast Carcinoma Patients

Abstract

Background - Breast cancer has always been diverse disease with various phenotypes and distinct biological features. It ishas becomehazardous disease which badly affects health of female. The current overall risk of death is about 20%. Immunohistochemistry is used for cancer diagnosis. Galectin-3 is a 30 kD protein which is part of non-integrin beta galactoside binding lectin family and plays a role in the process of cell adherence, cell cycle regulation, apoptosis, and cell repair. Galectin-3 plays an important role in complex gene expression regulation depending on the type of cell. This study aims to compare galectin-3 expression with Nottingham Grading System grading in histopathology in patients diagnosed with carcinoma breast and assess the aggressiveness of the tumour.Objectives - To acknowledge the association between galectin-3 expression and the Nottingham histological grading system in carcinoma breast.Methods – The present study is an observational, cross sectional and retrospective study to be conducted for a duration of two years from (October 2020 to October 2022) in the Histopathology and Immunohistochemistry Department of Pathology, Jawaharlal Nehru Medical College, Sawangi (Meghe), in coordination with the Department of General Surgery, Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe). Approval will be obtained from Institutional Ethics Committee and informed consent will be taken from the patients participating in this study.In this study we will correlate galectin-3 expression in patients diagnosed with breast cancer on histopathology with grading according to the Nottingham Grading System and determine the aggressiveness of the tumour.Results- The findings will be tabulated.Conclusion - Conclusion will be drawn from the results obtained from the study.