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Telomeres are the ends of humans linear chromosomes that comprise repetitive nucleotide sequences.Telomeres help to maintain chromosomal stability. Telomere length reduces with each somatic cell division, ultimately telomere length will be shortened. Telomere shortening can be avoided by the activity of telomerase enzymatic reaction,which are present in germ line, stem, and immune cells but are unavailable in somatic cells. A shelterin complex connects telomeres, controlling their span and keeping them from damage. Cancer uses telomere conservation to persist an unregulated replicative process.As a result, it's critical to clarify how telomeres and associated proteins play a role in tumor development, growth, and treatment.The present article emphasizes the importance of various telomerase functions, including cancer features that were recently described. Emerging mechanisms for recognizing multiple elements of telomere.