Optimization of Approaches to the Treatment of Endometrial Pathology in Women in the Perimenopausal Period with Extragenital Pathology

Abstract

Prompt diagnosis of menopausal pathologies is one of the principal factors that affects the women life expectancy at the working age at the peak of social activity. The intensions of formation at risk groups are to improve the quality of women`s life in early menopause and to do the prevention ofdistant complications. Perimenopausal syndrome is accompanied by significant abnormalities in women`s body system in many different forms that depend on specific clinical symptomatic. The major aim of the work is to find clinically justificatedway of treatment of endometrial pathology in women in the age of 46 to 60 yearswith extragenital pathology. The main group of patients consisted of two groups that were then devidedaccording to the treatment and prevention approach,and were comparedto the control group of healthy women. The notable improvements in the fibrinolysis system were noticed in a Group 1 monthafter the beginning of the treatment. The Group 1 got magnesium supplements and prophylaxis against TEC. Eventually the cytological findings of the aspirates from the uterine cavity, indicated the absence of atypical or pre-tumorous processes after intrauterine craniocervical surgery. The results of the following research allow to developepathogenetically substantiated algorithm of treating patients with HPE and adenomiasisin the perimenopausal period (46–60 years old), and also to provide secondary prevention of somatic pathologies. Expected improvements included during next two years after received treatment are: absence of complaints during bimanual examination, decreased uterine size (ultrasound diagnostic), uterine endometrial thickness of 3-4 mm, pathomorphological examination of uterine cavity aspirates.