Association between Omentin-1 and Oxidative Stress in Patient with Myocardial Infarction and Possibility of Using Omentin-1 Level as a Marker for Subclinical Atherosclerosis.

Abstract

Background and aims: a recently recognized adipokine mediator omentin-1 has important role in the development of atherosclerosis and many other diseases  .The aim of this study was to investigate the association between omentin-1, Malondialdehyde and carotid atherosclerosis in patients with first attack of  myocardial infarction.

Methods:We enrolled randomly 60 male and female  patients with recent attack of myocardial infarction  intended to Kirkuk Hospital evaluated their serum level of  omentin-1 MDA, cholesterol and carotid intima media thickness values have been estimated .

Result:omentin-1 is inversely association with myocardial infarctionThe study showed that serum concentration of omintin-1has been   reduced significantly  in myocardial infarction  patients (126.15 ±25.68ng /ml)  than those of  control group (171.56± 34.44 ng/ml), as well as confirmed that  there is  a significant  negative correlation between the serum level of   omentin-1 and Malondialdehyde. the present study demonstrated  that the omentin-1 concentration in human blood is inverselycorelatedto the carotid intima-media thickness predicting the  involvement of omentin-1  in the development of atherosclerosis plague.

Conclusions: the resultsof this study introduced  omentin-1 as a cardio protective adipokine, and indicate that  reduction in the serumomentin-1 levels could contribute to the stimulate of cardiovascular dysfunction