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Chronic Kidney Disease (CKD) is defined as defects of kidney structure or function, start for more than 3 months, lead to implications for health. .
In this study, included 152 of the samples (94 patients with CKD and 58 healthy), chronic kidney disease cases in stage before ESRD were diagnosed by specialized doctors. The purpose of this study to review of the impact of various inflammation factors, including interleukin 17F (IL-17F), and CXCL5 which may influence on the augmentation of chronic kidney insufficiency.
The serum levels of IL-17F and CXCL5 were determined by using ELISA technique. The results demonstrated that significantly (p<0.0001) Increased of IL-17F and CXCL5 serum level in CKD group than control due to their pro inflammatory role.