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Glucocorticoids in-general are considered the most powerful and efficient treatment for asthma. The following investigation was aimed to study the effect of the glucocorticoid receptors (NR3C1) rs10052957 (Tth111I), rs41423247 (BclI) the single nucleotide polymorphisms (SNPs), on the susceptibility to asthma in children as well as assessing its effect on the response to corticosteroids (ICS). A case-control study was conducted by 200 children were diagnosed with asthma; their ages ranged from 5 to 17 years old. They subdivided into two groups: 100 patients and 100 apparently healthy as a control. The polymorphisms (Tth111I (rs10052957), BclI (rs41423247) were genotyped using QT PCR method. The obtained results were analyzed using SPSS, and Linkage disequilibrium analysis was performed using Haploview. A significant variance was observed between the asthmatic group and the control group regarding the BclI (rs41423247) genotype. Among the patient's group, The CC genotype was 24.0 %, and the control group was 6.0 % with P-value (0.00). The GC genotype was statistically associated with an increase in the risk of asthma. No statically significant difference was found on Tth111I (rs10052957) for the studied groups. The results exhibited the association of NR3C1 gene polymorphism rs41423247 to provides risk allele for individual susceptibility to developing asthma with CC genotype while the (rs10052957) showed no association risk for exposure to developing asthma in children.