A Study of Correlation between Cholelithiasis and Hypothyroidism (Subclinical or Clinical) in a Rural Set Up

Abstract

BACKGROUND: It is found in various studies worldwide that there is a correlation between the two diseases namely Cholelithiasis and hypothyroidism. It is proposed that due to lack of thyroxine hormone there is decreased inhibitory effect (relaxation effect) on the sphincter of Oddi causing stasis of bile and in turn development of Cholelithiasis. Therefore in a case Cholelithiasisanalysing the thyroid hormone levels as well as in a case of hypothyroidism analysing the patient for any evidence of Cholelithiasis is going to be helpful in avoiding the potential complications.

PRIMARYOBJECTIVE : To establish if there is any correlation between Cholelithiasis and hypothyroidism (clinical and subclinical)

SECONDARYOBJECTIVES:

1) To evaluate correlation of cholelithiasis and hypothyroidism in different age groups and in relation to gender.

2) To evaluate this correlation with reference to sites of biliary stone( Gall bladder, CBD, pancreatic duct)

3)To evaluate the frequency of subclinical hypothyroidism in cholelithiasis.

4) To evaluate the relation of BMI, Obesity with Hypothyroidism and Cholelithiasis.

METHODS: All the patients above the age of 12 years will be considered for the study after being eligible for all the criterion. Patients with evidence of Cholelithiasis will be screened for subclinical or clinical hypothyroidism by TFT. On the other hand, the patients presenting with hypothyroidism will be screened for any evidence of Cholelithiasis by abdominal ultrasound.

RESULT: We expect that we will be able to establish a correlation between hypothyroidism and Cholelithiasis hence establishing hypothyroidism as one of the etiological factors for Cholelithiasis.

CONCLUSION: Expecting to establish a correlation between the Cholelithiasis and hypothyroidism.