The Correlation between Catalase C262T Gene Polymorphism and Catalase Enzyme Activity in Breast Cancer Patients

Abstract

Oxidative stress is known to be one of the major factors involved in thedevelopment and progression of cancer. Oxidative stress is significant in numerous types of cancer. Catalaseplay important roles in the primary defense against oxidative stress. The purpose of this study was to investigate the effects of the CAT C-262T (rs1001179) gene polymorphisms and catalase activity  on the susceptibility to breast cancer. The present results revealed that significant difference was observed in the rs1001179 CAT C-262T SNP between the patients and controls. We found that the genotypic frequency of heterozygous C/T with homozygous C/C (OR=22.20, 95% CI=1.287to 382.71, P= 0.0328). and the genotypic frequency of homozygous variant T/T with the homozygous C/C(OR=1.48,95% CI= 0.270 - 8.19, P=  0.64). There were a significant differences in T allele frequencies in patients as compared to the controls inthe CAT C-262T polymorphism (OR= 3.50, 95% CI: 1.1701 - 10.4, P=0.0250). The were no significant differences between catalase genotypes (CC,CT and TT) and its  activity  in serum  of breast patients and control ,Our findings showed that there wassignificant association  between CAT C-262T (rs1001179) polymorphism and Breast  cancer susceptibility.