Toxic Effect of Silver Nanoparticles on Some Hematological Parameters and Possible Preventive Role of Moringa Oleifera : In Vivo

Abstract

Toxicity research is conducted on animals in vivo, specifically mammals like rats, since they have a biological configuration similar to humans. Since the last ten years, the total of those research that have studied and analyzed the toxic influences of NPs has jumped up for the presence of these particles in several consumer products for humans . In this study, 24 male rats were divided into 4 groups, and each group comprised 6 rats. The control group (CON) were healthy rats without any treatment. Whereas, (AgNPs) group received 50 μl / kg silver nanoparticles for 30 days, and in ( AgNPs + MO) group, rats were co-administered from the combination of AgNPs at a dose of 50 μl / kg with Moringa Oleifera at a dose of 300 mg / kg for 30 days. Experimental animals of the (MO) group were treated with 300 mg / kg of MO for 30 days. Some blood parameters were measured using an automatic blood analyzer. Where the rats treated with AgNPs showed a tremendous decrease (p <0.05) in red blood cell counts (RBCs), hemoglobin concentration (Hb), and hematocrit value (Hct), in contrast to white blood cell counts contrasted to the control group. Then, the co-administration of M. Oleifera with AgNPs had a significant role and influence on haematological disorders. As a conclusion, these results demonstrated that M. Oleifera had a positive effect against the haematological toxicity of AgNPs in male rats.