Vitamin-D Levels in Neonates with and without Sepsis: A Case Control Study

Abstract

BACKGROUND:Neonatal sepsis is a syndrome comprising of non-specific symptoms and signs of infection accompanied by bacteraemia in first 28 days.vitamin D is a hormone which is steroid and fatsoluble vitamin. It has a vital importance in the active function of  the innate immune system by activating anti-microbial peptides .There are few epidemiological evidence showing a relation between low levels of vitamin d levels and its association with neonatal sepsis.Vitamin D not only plays a role in calcium and phosphorous homeostasis but also in immune function. Vitamin D receptors are present in epithelial cells and cells of immune system.

AIM:To study the role of vitamin d levels in neonates with sepsis.

OBJECTIVE:The objective is to measure vitamin D levels in neonates with probable sepsis and culture proven sepsis and neonates without sepsis and correlate levels of vitamin D in neonates with and without sepsis.

METHODOLOGY:This will be a case control study which will be done in NICU ,department of Pediatrics in Jawaharlal Nehru Medical College and AVBRH hospital ,Sawangi,Wardha from Nov 2020 to oct 2022.Neonates with probable sepsis and culture positive sepsis will be considered as cases .Neonatal and maternal  details ,examination and required investigations will be  recorded and relation , between vitamin d levels and neonatal sepsis will beassessed.

EXPECTED RESULT: We expect that vitamin D deficiencymight predispose to neonatal sepsis

CONCLUSION:There might be significant relationship between low levels of vitamin D levels and neonatal sepsis.