Effect of Metoclopramide on G6PDH Activity in First Trimester of Pregnancy

Abstract

The aim of this study was to investigate effect of Metoclopramide drugs on G6PD and antioxidant enzymes. Metoclopramide drugs are currently being used to Reduce or prevent nausea and vomiting in patients. This is the first study to show effect of Metoclopramide on glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzyme activities in first trimester in pregnancy. For in vitro studies, G6PD was purified from human erythrocyte Metoclopramide hydrochloride showed no inhibition effects