A Review of Drug Target Interaction Prognostication Using Artificial Intelligence

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K. Nandhini, Dr. G. V. Sriramakrishnan


Identifying new Drug-Target Interactions (DTIs) plays avital role in the drug discovery and repositioning phase as the effectiveness of currently available antibiotics declines. Drug target interaction is described as the fastening of a drug to a particular target that causes changes its actions or functions. Medicinal targets, a particle in a body, for example, some proteins and nucleic acids, which is essentially correlated with a disease process and that, could be treated by a medication in order to attain the intended curative effect. Drug Interaction is not only assisting the understanding of disease processes, but it also aids in the detection of unusual remedialaction or medication ill effects. . Drug-target relationship prognostication allows researchers to better understand drug activity, disease pathology and drug side causes. Hence, the prediction of drug-target interaction is an important arena of medicine detection and reusing. In contrast to wet-lab experimentations that cause expensive and time-consuming experimental methods, Artificial intelligence is critical for identifying DTIs in a way that is accurate, reliable, and high-throughput. Nowadays computational methods help to predict the interactions and they do so with reasonable accuracy. This paper reviews the various methodologies used in Artificial Intelligence and the computer-based methods for foreseeingthe biological targets and the datasets used to forecast the collaboration.

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K. Nandhini, Dr. G. V. Sriramakrishnan. (2021). A Review of Drug Target Interaction Prognostication Using Artificial Intelligence. Annals of the Romanian Society for Cell Biology, 832–838. Retrieved from https://www.annalsofrscb.ro/index.php/journal/article/view/4424