Synthesis of Dihydropyrimidone Derivatives by Application of Organic Red Clay and their Anti-Microbial Screening

Abstract

The organic red clay used as heterogenous catalyst for the one-pot Biginelli reaction in mild conditions; good to excellent yield of the desired 3,4-dihydropyrimidone derivatives was obtained in short reaction time. Powder XRD (X-ray Diffractometer), SEM-EDX (Scanning Electron Microscope- Energy Dispersion X-ray) analysis was carried out to characterize the red clay. Crystallite size of clay calculated from XRD spectra. The synthesized compounds examine using proton NMR, carbon NMR & FTIR spectroscopic studies. The reaction was carried out under solvent-free condition, using microwave heating. An environmentally benign procedure, recovery of catalyst, & short reaction time are some of the important features of this novel protocol. In addition, synthesized compounds were screened for their anti-microbial properties against two bacterial pathogens & one fungi. Most of products demonstrated higher to moderate anti-microbial actions.