Evaluation of Serum Cystatin C Level in Patients with Diabetic Nephropathy

Abstract

Background: Diabetic Nephropathy is one of Diabetes mellitus complication at micro vascular level that lead to final stage of renal disease .It is has many features include function and morphologic changes of renal such as increase of albumin level in urine and increase density of glomerular basement membrane .Cystatin C is protein has low molecular weight  and it is has many features such as freely filtrates by glomeruli and not  affected by sex , diet and age .

Objective of the Study: Evaluation of serum Cystatin C concentration in DN patients.                                                                                                          

Materials and Methods: This study was done on 50 patients with DN disease and 50 healthy persons (control ), the all subjects age within this study were more than 50 years of both genders, the disease duration was more than 10 years .After obtained serum , immediately used quantity method (immunoassay) for measured level of Cystatin C concentration .

Results: This study shows elevation of serum Cystatin C level in DN group compare with control group .

Conclusion: This study confirms that serum cystatin C level can use as early marker to diagnosis of DN patients in early stage.