Association Risk of Metalomatrix Proteinase Enzymes Levels (MMP-1,MMP-9 And MMP-13) with Development of Rheumatoid Arthritis

Abstract

    Matrix metalloproteinase are family of metalloendopeptidases  enzymes play a critical role in degrade of extracellular matrix components in rheumatoid arthritis patients . This study aims to assess the association  of MMP1,9,13 with the development of rheumatoid arthritis disease . The study included 69 RA patients positive for RF factor .MMPs concentration is measured by sandwich  ELISA technique .The results showed that the  MMP-1, 9 ,13 levels are significant increase in rheumatoid arthritis patients compared with control group . Only MMP1 showed a significant differences regarding the period of rheumatoid arthritis disease. However ,no association between the levels of MMP-1, 9 ,13 with gender, age group of patients , activity of disease and associated diseases with RA . Highly positive correlation was showed  between MMP-1 and MMP-9 levels in RA patients. Our study concluded there was an association between the increase of MMP-1, 9 ,13  levels with development of rheumatoid arthritis in Iraqi patients , while MMP1 is associated with the early detection of rheumatism.