SOX4 as Prognostic Significance for Individual's Exposure to LDIR

Abstract

     X-ray impacts on the systems of human body, some the used techniques recognize molecular properties at the exposure of X-ray   .The detection of SOX4 (SRY-related HMG-box gene4) the expression via QRT- PCR consider essential technique in the current work. The X-ray genotoxicity can observe    in low dose such as  1cGy, depending on  the Center of  Radiation Protection,  there workers   exposed  to weak dose  from γ-rays  about ( 2- 10) cGy. The groups involved the (exposure group) twenty, also the workers in Radiographerthat existing close to the  source (X-ray) , (control group )  consist of five volunteers   from male at various age,  they didn't  subject to any radiations  whether   x-ray  or radiotherapy. Whole blood collects   of all persons. The finding appear that   the expression of SOX   increased   in individuals exposed for more than 1cGy , and decreasing  in control group . The little doses of X-rays lead to genotoxicity then increased the expression set of genes that responsible of   repairing   such as XRCC1, XRCC2,XRCC3 and other genes like FOXM1 , the SOX gene is one of these genes was Stimulates by oxidative stress of X-ray . SOX4, as one of the SRY-associated HMG-box (SOX) which considers from the family of transcription factor and it has been proved to be participated in the tumorigenesis for many malignancy in human.These study depending on Previous treatise it indicated a correlation between expression in FOXM1and  SOX4