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Sciatic nerve injury causes damage to the muscles and a lack of movement. Effective treatment for this disease is still being studied. This study used the basis of treatment of sciatic nerve injuries with Curcumin and aerobic training and involved the analysis of the neuronal regeneration of brain nerve cells upon damage or injury. Therefore, this research aimed to analyze and determine the effect of the curcumin medicine administration on the proteins in the nerve cells that trigger the regeneration of the sciatic nerve cell that is GAP-43 and S100. The posterior vertebral columns sciatic nerves from mice (young 7-10 days and a middle-aged 4-6 weeks old) were used in this study. Immunocytochemistry and luxol fast blue staining were performed to analyze tissue and protein. Real-time Polymerase Chain Reaction and Bioinformatics analysis study were used in this study. The analysis results show a close correlation between curcumin's medication and the regeneration of the nerve cell. The hypothesis of the study was somewhat confirmed of a correlation of Curcumin and the proteins that is GAP-43 and S100. The study's test results comparison confirmed the relationships between the drug and the proteins.